Past Project

Mycoplasma bovis pneumonia and arthritis in feedlot cattle

Executive Summary


  • Identify evidence of damage mediated by hydrogen peroxide or other oxygen radicals in the characteristic caseonecrotic lesions caused by Mycoplasma bovis.
  • Determine whether Ontario strains of Mycoplasma bovis produce hydrogen peroxide in differing amounts and whether these differences correlate with the presence or absence of disease.



  • Oxidative damage is present in lung lesions of M. bovis bronchopneumonia, although it mainly affects foci of coagulative (blood clots) and to a lesser extent those of caseous necrosis, and is less extensive than seen in cases of Mannheimia haemolytica pneumonia.
  • There was a slightly higher mean production of hydrogen peroxide in M. bovis isolates from lesions of caseonecrotic bronchopneumonia compared to M. bovis isolates from other forms of pneumonia.
  • This finding does not support the idea that increased virulence of certain strains is important, and instead supports researcher’s prior findings that the lesions of Mycoplasma bovis pneumonia develop out of the lesions of shipping fever pneumonia.
  • This concept suggests that control of shipping fever may be of value in reducing the prevalence of Mycoplasma bovis pneumonia.

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